succinic acid pka

Thirdly the display of data is prioritised by units . Biodegradation in water provides information on the substance’s biodegradation properties in water and can be registered by the registrants by one or more of the following picklist options: This section summarises the values related to the simulation tests for biodegradation in water and sediments from all registered dossiers for the substance. 1 36381 Schluechtern Germany, UMICORE Galvanotechnik GmbH, 53-79 Klarenbergstrasse 73525 Schwäbisch Gmünd Germany, BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland, ExponentOR41, The Lenz Hornbeam Business Park HG28RE Harrogate Yorkshire United Kingdom, OQEMA Contract GmbH, OR1, Nauheimer Strasse 37 70372 Stuttgart Germany, Showa Denko Europe GmbH OR1, Konrad-Zuse-Platz 3 D-81829 Munich Germany, Gas under pressure: refrigerated liquefied gas, Solid: nanomaterial, no surface treatment, Characteristic of sulphur containing compounds, Self-heating substances and mixtures (Cat. This section summarises physical and chemical property values from all registered dossiers in ECHA’s databases for the substance. Bacteria and plants can produce succinate from acetate or acetyl CoA, in the glyoxylate cycle. This Brief Profile is covered by the ECHA Legal Disclaimer. Data is generally displayed in milligrams per litre. level’ as the dose descriptor. Contents. If so, the data provided is not processed for the Brief Profile. CAS names gives the name(s) provided to ECHA by the Chemical Abstracts Service, a division of the American Chemical Society, where available. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Values are generally displayed in milligram per litre. This section provides environmental fate and pathways information compiled from all registered dossiers for the substance. This section summarises the values related to phototransformation in water from all registered dossiers for the substance. Values are generally displayed in milligram per kilo food. 110-15-6. These substances cannot be placed on the market or used after a given date, unless an authorisation is granted for their specific use, or the use is exempted from authorisation. Considering the pKa of succinic acid of 4.2 and 5.6 at 25 C (Dean, 1999), at pH 3.5 more than 80% of succinic acid would be in protonated form. Notification – indicates that notified C&L’s have been submitted to ECHA for a substance. A MAK value of 2 mg/m 3 I (inhalable fraction) has been established for tartaric acid in analogy to phosphoric acid ( documentation “Weinsäure” 2015 , available in German only). Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Malonic acid and succinic acid each have two different pKa values. Other names gives any names of any other type, such as common names, synonyms and acronyms. Due to the number of the substances and the associated information, substance data is processed and aggregated in an automatic process. This substance is used in the following products: pH regulators and water treatment products. Release to the environment of this substance can occur from industrial use: formulation of mixtures. Registrants can register their substance explosiveness as: Explosiveness. Succinic acid is a diprotic acid. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Succinic acid (Succınıc acıd) exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. minadepiedras.com. Due to the quantity of information and the number of chemicals, the Brief Profile is automatically generated based on the information available and is not manually verified. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. Study data not processed for brief profile. This section summarises the values related to toxicity to aquatic algae and cyanobacteria from all registered dossiers for the substance. example@lookchem.com, Please enter your password with 6 - 20 characters, Your message must be between 20-2000 letters. If more than one numerical result is available per endpoint, the range of results (min-max) will be presented (RANGE method). The CLP regulatory processes identified for the Brief Profile are: The BPR (528/2012) entered into force on 1 September 2013. If so, the data provided is not processed for the Brief Profile. All the source data on which the summaries on this page are based, is provided by industry and stored in the ECHA databases. More information on processable studies and data-waiving is available in the section help of the ‘Scientific properties’ header. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain, MOEHS CATALANA, Cesar Martinell i Brunet 12 A 08191 Rubi Barcelona Spain, PURAC bioquímica, Gran Vial 19-25 08160 Montmeló (Barcelona) Spain, REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland, ROQUETTE ITALIA SPA, Via Serravalle 26 15063 Cassano Spinola Alessandria Italy, SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany, Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom, TRIGON Chemie GmbH, Breitwiesenstr. ECHA has no public registered data on the use of this substance in activities or processes at the workplace. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). Succinate dehydrogenase (SDH) plays an important role in mitochondrial function, being both part of the respiratory chain and the Krebs cycle. If more than one numerical result is available per endpoint, the range of results (min-max, RANGE method) will be displayed. Anonymous. Log Koc at 20°C provides substance information on the substance’s log Koc adsorption at a temperature 20 °C. The Brief Profile summarises the non-confidential data on substances as it is held in the databases of the European Chemical Agency (ECHA), including data provided by third parties. Registrants can report substance information on viscosity as: Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C. Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. For this endpoint registrants do not provide study results that are processable for the Brief Profile. The Brief Profile is automatically generated; information requirements under different legislative frameworks may, therefore, not be up-to-date or complete. Succinic acid: Description: Succinic acid is a dicarboxylic acid. The Agency thus cannot guarantee the correctness of the information displayed. Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)The REACH Regulation (1907/2006) entered into force on 1 June 2007. Other names. Registrants can register their substance’s bioaccumulation properties as: Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages. Water solubility provides substance information on the substance’s solubility in water in grams per litre at a temperature measured in °C. Registrants can identify their substance as being a mono-constituent substance, multi-constituent substance, UVCB, polymer or specify another type. The structure is a computer generated visualisation of the molecular structure derived from the InChI character string. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight). Registrants can register their substance’s flammability as: This section summarises the explosiveness values from all registered dossiers for the substance. If there are additives and impurities relevant for the substance classification, these are also indicated. This section summarises the values related to toxicity to mammals (other above-ground organisms) from all registered dossiers for the substance. EC Inventory, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances, EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM and Articles Regulation, Annex I - Authorised Substances. Processable data for study results is prioritised by dose descriptor type (see list below) and subsequently further prioritised by the test species. If multiple values are available, the most conservative value (the highest percentage) is displayed. Dynamic viscosity at 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C. Values are presented in (nano/ micro/milli)gram per litre and/or (nano/ micro/milli)molar per litre. The goal of CLP is to make sure that hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through a system of classifying and labelling of chemicals. This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). Annex V – indicates if the substance is prohibited from export. The REACH regulatory processes identified for the Brief Profile are: Persistent Organic Pollutants (POPs)The POPs Regulation (EU) 2019/1021 entered into force on 15 July 2019, repealing the previous POPs Regulation (EC) No 850/2004. Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight). 2-methylbutanedioic acid is a dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. This section summarises the values related to the screening tests for biodegradation in water from all registered dossiers for the substance. 110-15-6Nature and use: A white crystal with a melting point of 185 ℃, a boiling point of 235 ℃ (decomposed into anhydrides) and a specific gravity of 1.572. 3 Data is generally displayed in milligrams per kilogram in the case of soil (dry/wet weight), or gram per hectare. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. The source of the information is mentioned in the introductory sentence of the hazard statement. Dissipation half-life provides substance information on the substance’s dissipation half-life for the parent compound per second/minute/hour/day/week/month/year. Use descriptors were adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes description as in ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. The pKa values for succinic acid, pKa 1 = 4.61 and pKa 2 = 5.61, lie below the optimal growth and production pH of many organisms. EC10 / LC10 or NOEC for freshwater fish provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater fish or the no observed effect concentration. Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. Succinic acid (CAS No.110-15-6 ) also known as butanedioic acid, asuccin, amber acid, succinicum acidum, katasuccin, bernsteinsaure, dihydrofumaric acid, succinate, kyselina jantarova is a is a common natural organic acids. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. List of substances subject to the POPs Regulation - Indicates if the substance is included in the POPs Regulation. Different compositions or impurity profiles often lead to different classifications. Please see the endpoint help sections for more specific information on the sections or see the ‘Scientific properties’ header for a more complete overview. This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance. ... pKa at 20°C provides numerical substance information on the dissociation constant in pKa at a temperature of 20°C. List of substances proposed as POPs - Indicates if the substance has been proposed for its inclusion in the Stockholm Convention or if a proposal is under preparation in the European Union. Short-term EC50 or LC50 for birds provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of birds in the test, generally displayed in milligram per kilo food. Registrant can provide information on eye exposure by selecting one of the following hazard assessment conclusions: Data for general population – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for the general population). Log Kd provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. Hazard to aquatic organisms provides information on the substance’s hazard assessment conclusion regarding aquatic organisms. 2 This section summarises the values related to hydrolysis from all registered dossiers for the substance. Dossier evaluation – indicated if at least one registered dossier for the substance has been evaluated under REACH for compliance check or testing proposal evaluation and associated decision(s) published on the ECHA website. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight). The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH). ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. REACH registration dossiers have greater data requirements (support studies) than notifications under CLP. Values are displayed in milligram per litre. In most cases, impurities constitute less than 10% of the substance. The availability of additional data beyond the five results displayed is indicated by (…). At concentration of 1 mM, it has a pH of 3.65. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. If so, the data provided is not processed in the Brief Profile. If more than one value is found for this section, the range of min-max values will be displayed here. PNEC aqua, displayed in milligram per litre. O. As the critical effect is local, succinic acid is assigned to Peak Limitation Category I. See information under ‘Study results oral’. Data is generally standardised and displayed in milligram per kilo soil (dry weight). This section provides an overview of the type of study records behind the presented results and – if applicable - data waving justifications. Succinic acid pKas: 4.20 and 5.60. This section summarises the pH values from all registered dossiers for the substance. Please see Registrants/Suppliers details. PBT properties are derived from REACH registered substances dossiers. This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. The IUPAC nomenclature is a systematic way of naming chemical substances, both organic and inorganic. This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals, transfer of substance into small containers and closed processes with no likelihood of exposure. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. H atm provides substance information on the substance’s Henry’s Law Constant in atm at temperature measured in °C and a pressure measured in Pascal. EC10 / LC10 or NOEC for freshwater algae provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater algea or the no observed effect concentration for freshwater algae. Therefore this does not constitute official and legally binding information. Examples include recommended measures on fire-fighting, transport, recycling and disposal. ThOD provides substance information on the substance’s ThOD values displayed in O2 (milli)gram per gram test material. Buffers pKa range . Succinic acid, when produced through fermentation, converts glucose to succinic acid along a portion of the reductive cycle of the tricarboxylic acid (TCA) cycle [Lee et al.,2002].Figure 2-3 depicts the reactions and enzymes in a typical fermentation process that transforms glucose to succinic acid. C&L Inventory . If no data is available in the registered substance dossiers, this will be indicated by a notification stating ‘Data not provided by the registrant’. This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. Posuere sit amet nunc how we use cookies endpoint conclusions as mentioned under ‘ applicant ’ dissipation... Of soil ( dry/wet weight ) glyoxylate cycle, Less Uncertainty for each substance is most likely be... Additives and impurities relevant for the substance ’ s dissipation half-life in water in.... 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And chemical property values from all registered dossiers for the substance ’ s hazard assessment conclusions regarding exposure... 1 September 2013 burning rate equal or higher than reference mixture, oxidising: vigorous reaction in preliminary test classification!

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